3-Methoxybenzenesulfonyl chloride(CAS: 10130-74-2)

3-Methoxybenzenesulfonyl chloride is a white crystalline solid with a molecular weight of approximately 228.21 g/mol. It has a low water solubility but is soluble in organic solvents. It is highly reactive, especially towards nucleophiles, and is used in various synthetic reactions.

3-Methoxybenzenesulfonyl chloride is typically synthesized by sulfonylation of 3-methoxybenzene using thionyl chloride. The reaction is performed under anhydrous conditions and is exothermic, yielding a selective and efficient product with good yield.

3-Methoxybenzenesulfonyl chloride is primarily used in the pharmaceutical and polymer industries for the synthesis of intermediates. It is also used in the production of sensors and semiconductors due to its reactivity and chemical stability.

When handling 3-Methoxybenzenesulfonyl chloride, it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area, preferably under a fume hood, to avoid exposure. Spills should be handled carefully and according to the Material Safety Data Sheet (MSDS).