Ethyl 6-bromo-1H-indazole-3-carboxylate(CAS: 885272-94-6)

Ethyl 6-bromo-1H-indazole-3-carboxylate (CAS: 885272-94-6) is a white crystalline solid with a molecular weight of approximately 281.03 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and ethanol. Chemically, it is moderately reactive, particularly towards nucleophilic substitution reactions. It exhibits good stability under normal storage conditions but should be protected from strong reducing or oxidizing agents.

Ethyl 6-bromo-1H-indazole-3-carboxylate is synthesized through a multi-step process involving the synthesis of 1H-indazole followed by alkylation with ethyl bromide, followed by acylation with ethyl chloroformate. The reaction typically requires the use of a base like triethylamine and is achieved with high yield and selectivity. The process is conducted under standard laboratory conditions, with appropriate handling of bromine and ethyl bromide due to their reactivity.

Ethyl 6-bromo-1H-indazole-3-carboxylate (CAS: 885272-94-6) is primarily used in the pharmaceutical industry due to its potential as a precursor in the synthesis of various bioactive compounds. It also finds applications in the chemical industry for its reactivity in organic synthesis and in the development of new materials. This compound is less commonly used in the polymer or semiconductor industries but can be utilized in specialized applications requiring its specific reactivity.

When handling Ethyl 6-bromo-1H-indazole-3-carboxylate (CAS: 885272-94-6), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or fume hood due to its potential for respiratory irritation. Spills should be cleaned up immediately with appropriate absorbent materials. For more detailed safety information, refer to the Safety Data Sheet (SDS) for this compound.