2-Methyl-1,2-thiazol-3(2H)-one - 5-chloro-2-methyl-1,2-thiazol-3(2H)-one (1:1)(CAS: 96118-96-6)

5-Chloro-2-methyl-1,2-thiazol-3(2H)-one (CAS: 96118-96-6) is a white crystalline solid with a molecular weight of approximately 165.01 g/mol. It is slightly soluble in water and more soluble in organic solvents. The compound is known for its high reactivity, particularly in nucleophilic substitution reactions. It is stable under normal conditions but should be stored away from moisture and heat to prevent degradation.

5-Chloro-2-methyl-1,2-thiazol-3(2H)-one (CAS: 96118-96-6) is typically synthesized via a condensation reaction between chloroacetyl chloride and 2-methylthiazole. The reaction is catalyzed by anhydrous aluminum chloride. The yield is around 85%, and the product is isolated by recrystallization from ethanol. The reaction is conducted under anhydrous conditions to ensure high purity and selectivity.

5-Chloro-2-methyl-1,2-thiazol-3(2H)-one (CAS: 96118-96-6) is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of bioactive compounds. It is also used in the preparation of certain dyes and pigments, as well as in the synthesis of sensors and semiconductors due to its unique electronic properties.

When handling 5-Chloro-2-methyl-1,2-thiazol-3(2H)-one (CAS: 96118-96-6), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handle in a well-ventilated area or fume hood to avoid inhalation of vapors. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed information on safe handling and disposal.