2-Bromo-3-methyl-5-nitropyridine(CAS: 23132-21-0)

2-Bromo-3-methyl-5-nitropyridine is a crystalline solid with a molecular weight of approximately 223.02 g/mol. It is slightly soluble in water but soluble in organic solvents such as ethanol and acetone. The compound is known for its high reactivity, especially towards nucleophiles and reducing agents.

2-Bromo-3-methyl-5-nitropyridine is typically synthesized via the nitration of 3-methyl-2-pyridineboronic acid followed by bromination. This process requires careful control of reaction conditions to ensure high yield and selectivity. Commonly used reagents include nitric acid and bromine in the presence of a phase transfer catalyst.

2-Bromo-3-methyl-5-nitropyridine is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds applications in the production of sensors and as a precursor in the development of new materials. Additionally, it is used in the semiconductor industry for specific chemical processes.

Handling 2-Bromo-3-methyl-5-nitropyridine requires strict safety measures due to its reactivity. Always wear personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store it in a cool, dry place away from sources of ignition. Handle in a well-ventilated area or fume hood to avoid inhalation. In case of spill, immediately clean up using appropriate materials and consult the Safety Data Sheet (SDS) for further guidance.