4-Chloro-5-fluoro-2-methylpyrimidine(CAS: 898044-50-3)

4-Chloro-5-fluoro-2-methylpyrimidine is a white to off-white crystalline solid with a molecular weight of approximately 183.02 g/mol. It is slightly soluble in water but soluble in common organic solvents like DMF, DMSO, and acetonitrile. The compound is chemically stable but can react with strong bases. It has a melting point of around 230-232°C.

4-Chloro-5-fluoro-2-methylpyrimidine is usually synthesized via the reaction of 2-chloro-5-fluoropyrimidine with methylamine. The reaction is typically carried out in the presence of a base like sodium hydride to improve yield and selectivity. The exact conditions can vary, but the yield is often around 70-80%.

4-Chloro-5-fluoro-2-methylpyrimidine is used primarily in the pharmaceutical industry for the synthesis of various drug candidates. It is also utilized in the polymer industry for the development of new materials with specific properties. Additionally, it finds applications in the sensor and semiconductor fields due to its chemical characteristics.

When handling 4-Chloro-5-fluoro-2-methylpyrimidine, appropriate personal protective equipment (PPE) should be worn, including gloves, safety glasses, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to prevent inhalation. In case of a spill, it should be carefully cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.