3-Bromo-5-nitropyridin-4-amine(CAS: 89284-05-9)

3-Bromo-5-nitropyridin-4-amine is a solid at room temperature, with a crystalline form. Its molecular weight is approximately 243.02 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and dimethylformamide. The compound is moderately reactive, particularly towards nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

3-Bromo-5-nitropyridin-4-amine is synthesized through a multi-step process, often involving the bromination of 5-nitropyridin-4-amine followed by amination of 5-bromopyridin-4-amine. Commonly, this involves using bromine and a Lewis acid catalyst like aluminum bromide. The reaction yields a product with excellent selectivity, and the overall yield is typically around 70-80%.

3-Bromo-5-nitropyridin-4-amine is used in various industries, particularly in the pharmaceutical industry for synthesizing complex organic compounds and drug candidates. It is also utilized in the production of certain chemical sensors and materials for semiconductors. Its application in polymer chemistry is less common but still relevant.

When handling 3-Bromo-5-nitropyridin-4-amine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to avoid inhalation of fumes. Spills should be cleaned up immediately using appropriate absorbent materials. Consult the Safety Data Sheet (SDS) for detailed information and emergency procedures.