1,3,5-Trifluoro-2-nitrobenzene(CAS: 315-14-0)

1,3,5-Trifluoro-2-nitrobenzene (CAS: 315-14-0) is a crystalline solid with a molecular weight of approximately 211.07 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and dichloromethane. Chemically, it is a potent electrophile and nitro compound, showing good reactivity towards nucleophiles and reductants.

1,3,5-Trifluoro-2-nitrobenzene can be synthesized via the nitration of 1,3,5-trifluorobenzene, usually in the presence of an acid catalyst like sulfuric acid. The reaction is carried out under controlled conditions to achieve high yield and selectivity, with stoichiometric nitration being a common approach.

1,3,5-Trifluoro-2-nitrobenzene is primarily used in the pharmaceutical industry for the synthesis of drugs, particularly those requiring specific functional groups for modification. It also has applications in the polymer and semiconductor industries, where its unique chemical properties are utilized.

When handling 1,3,5-Trifluoro-2-nitrobenzene, always wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Store it in a well-ventilated area and use a fume hood during operations to minimize exposure. In case of spill, use appropriate spill kits and follow the safety data sheet (SDS) for disposal and cleanup procedures.