5-Amino-6-methylnicotinic acid(CAS: 91978-75-5)

5-Amino-6-methylnicotinic acid is a crystalline solid with a molecular weight of 157.19 g/mol. It has a solubility of 1.1 g/100 mL in water at 25°C. This compound is relatively stable under normal conditions but can react with strong acids and bases. It is not flammable and does not pose a significant fire hazard.

5-Amino-6-methylnicotinic acid is synthesized through the methylation of nicotinic acid followed by the amidation of the resulting methyl derivative. Commonly, this involves the use of methyl iodide and a base such as potassium carbonate in an aprotic solvent like dimethylformamide (DMF). The yield is typically around 70-80%, and the reaction is carried out under mild conditions.

5-Amino-6-methylnicotinic acid is used in various industries. It is an intermediate in the synthesis of pharmaceuticals, particularly as a precursor to certain drugs. It also finds applications in the production of polymers, where it serves as a stabilizer. Additionally, it is used in the development of sensors and as a component in some semiconductors.

When handling 5-Amino-6-methylnicotinic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.