1-(2-Methyl-2-propanyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one(CAS: 1455358-06-1)

1-(2-Methyl-2-propanyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one is a crystalline solid with a molecular weight of approximately 237.3 g/mol. It is slightly soluble in water and has a high solubility in organic solvents like methanol and acetone. Reactivity is moderate, showing some basic character and moderate nucleophilicity. It is stable under normal conditions but should be stored away from strong acids and bases.

1-(2-Methyl-2-propanyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one is typically synthesized through a multi-step process involving the condensation of an appropriate pyridine derivative with an acylating agent. Common catalysts include titanium(IV) isopropoxide, and the reaction proceeds with good selectivity and yield. The final product is purified by recrystallization or column chromatography.

1-(2-Methyl-2-propanyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also applicable in the polymer industry, where it can act as a stabilizer or additive, and in the sensor technology sector for its potential in developing highly sensitive detection systems.

Proper handling of 1-(2-Methyl-2-propanyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one requires the use of personal protective equipment (PPE) such as gloves, goggles, and lab coat. The substance should be stored in a fume hood and handled in a well-ventilated area. In case of spill, it should be cleaned up using absorbent material and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.