4,6-Dichloropyrimidine-5-carboxylic acid(CAS: 87600-98-4)

4,6-Dichloropyrimidine-5-carboxylic acid is a white crystalline solid with a molecular weight of approximately 247.03 g/mol. It has a solubility of about 0.4 g/L in water. The compound is known for its moderate reactivity, particularly towards nucleophilic substitution and condensation reactions.

4,6-Dichloropyrimidine-5-carboxylic acid can be synthesized through the condensation of 4,6-dichloropyrimidine with acetic anhydride. The reaction is catalyzed by phosphoric acid and typically yields a pure product with good selectivity and high yield.

4,6-Dichloropyrimidine-5-carboxylic acid is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry, where it serves as a monomer precursor, and in the development of sensors and materials for semiconductors.

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 4,6-Dichloropyrimidine-5-carboxylic acid. The reaction should be conducted in a fume hood to minimize exposure. In case of spill, use appropriate cleanup materials and consult the Safety Data Sheet (SDS) for further guidance.