7-Chloro-6-nitro-4(1H)-quinazolinone(CAS: 53449-14-2)

7-Chloro-6-nitro-4(1H)-quinazolinone (CAS: 53449-14-2) is a crystalline compound with a molecular weight of approximately 276.04 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards nucleophiles, making it suitable for various synthetic transformations. It can undergo nitration, chlorination, and other electrophilic reactions.

7-Chloro-6-nitro-4(1H)-quinazolinone is typically synthesized via the nitration of 7-chloro-4(1H)-quinazolinone followed by subsequent purification. Commonly, this process involves the use of nitric acid in the presence of sulfuric acid as a catalyst. The yield is usually around 70-80%, with good selectivity for the nitro group introduction.

7-Chloro-6-nitro-4(1H)-quinazolinone (CAS: 53449-14-2) finds applications in the pharmaceutical industry for its use as an intermediate in the synthesis of various drugs. It is also explored in the polymer industry for its potential as a photoinitiator and in the semiconductor industry for its use in organic thin-film transistors due to its electron-donating nature.

When handling 7-Chloro-6-nitro-4(1H)-quinazolinone (CAS: 53449-14-2), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and emergency response procedures.