(2R)-2-Amino-3-(1H-indol-3-yl)-1-propanol(CAS: 52485-52-6)

(2R)-2-Amino-3-(1H-indol-3-yl)-1-propanol is a colorless solid with a molecular weight of approximately 212.26 g/mol. It has a solubility of about 10 mg/mL in water. Chemically, it is reactive towards strong acids and bases. It crystallizes in a monoclinic form and has good solubility in organic solvents like methanol and ethanol.

(2R)-2-Amino-3-(1H-indol-3-yl)-1-propanol is synthesized via a multi-step process involving the reaction of 3-aminopropanol with 1H-indole. The synthesis typically employs catalytic hydrogenation and condensation reactions, yielding a product with high selectivity and good yield under controlled conditions. Commonly, palladium catalysts are used in the hydrogenation step.

(2R)-2-Amino-3-(1H-indol-3-yl)-1-propanol is utilized in the pharmaceutical industry for its role as a precursor in the synthesis of indole derivatives with medicinal properties. It is also found in research applications related to polymer science and the development of sensors and semiconductors.

When handling (2R)-2-Amino-3-(1H-indol-3-yl)-1-propanol, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent materials and disposed of according to proper waste disposal procedures. Always refer to the Safety Data Sheet (SDS) for detailed safety information.