Cidofovir Dihydrate(CAS: 149394-66-1)

Cidofovir dihydrate is a white crystalline solid with a molecular weight of approximately 597.62 g/mol. It has a high solubility in water and is poorly soluble in organic solvents. Chemically, it is a nucleoside analog with antiviral activity. It is reactive towards nucleophilic attack and can form stable complexes with metal ions, making it useful in various pharmaceutical applications.

Cidofovir dihydrate is typically synthesized through a multistep process involving the condensation of 2'-deoxyguanosine with 2-hydroxy-5-nitroimidazole-1-ylidene, followed by reduction and hydration. The synthesis involves the use of reagents such as sodium hydride and acetic anhydride. The yield is moderate, around 50-60%, and the reaction conditions are optimized for selectivity and purity.

Cidofovir dihydrate is primarily used in the pharmaceutical industry for the treatment of viral infections, particularly CMV retinitis in AIDS patients. It is also explored for its potential in other applications such as topical treatments for viral infections in the skin and mucous membranes. Limited use is seen in research and development for its reactivity and complex chemistry in various industries.

When handling Cidofovir dihydrate, it is important to wear appropriate personal protective equipment (PPE) including gloves and safety goggles. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of dust. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions to ensure safety and compliance.