Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate(CAS: 372198-69-1)

Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate is a crystalline compound with a molecular weight of approximately 285.05 g/mol. It has a low solubility in water but is soluble in common organic solvents like DMSO and DMF. This compound is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a dry place to avoid hydrolysis.

Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate is typically synthesized by the nucleophilic substitution of ethyl 6-iodimidazo[1,2-a]pyridine-3-carboxylate with bromide ion in the presence of a base such as sodium hydride. The reaction is carried out in a suitable solvent like DMF, leading to a good yield of the target compound with high selectivity.

Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate is used in the pharmaceutical and fine chemical industries for the synthesis of various bioactive molecules. It can also find applications in the development of sensors and materials science, particularly in the field of semiconductors and polymer science.

When handling Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. The compound should be handled in a well-ventilated fume hood to minimize inhalation risks. In case of a spill, immediately clean it up using appropriate absorbent materials and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.