Methyl (diethoxyphosphoryl)acetate(CAS: 1067-74-9)

Methyl (diethoxyphosphoryl)acetate (CAS: 1067-74-9) is a colorless to slightly yellow liquid with a molecular weight of approximately 241.24 g/mol. It has a high vapor pressure, making it volatile, and is slightly soluble in water. This compound is known for its strong reactivity, particularly in nucleophilic substitution reactions. It can form explosive mixtures with air and has a pungent odor.

Methyl (diethoxyphosphoryl)acetate (CAS: 1067-74-9) is typically synthesized through the reaction of diethyl phosphite with acetyl chloride in the presence of a mild base such as triethylamine. The reaction is known to be highly exothermic and requires careful temperature control to prevent decomposition. The yield can be up to 85%, depending on the purity of starting materials and reaction conditions.

Methyl (diethoxyphosphoryl)acetate (CAS: 1067-74-9) is used in various industries, including pharmaceuticals for the synthesis of certain compounds, polymers for modifying properties, and sensors for detecting specific chemical species. It is also employed in semiconductor manufacturing for cleaning and etching processes due to its reactive nature.

When handling Methyl (diethoxyphosphoryl)acetate (CAS: 1067-74-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled with caution, using absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and safe handling instructions.