Compound Q&A

How is Methyl (diethoxyphosphoryl)acetate (CAS: 1067-74-9) typically synthesized?

Answer

Methyl (diethoxyphosphoryl)acetate
Methyl (diethoxyphosphoryl)acetate (CAS: 1067-74-9) is typically synthesized through the reaction of diethyl phosphite with acetyl chloride in the presence of a mild base such as triethylamine. The reaction is known to be highly exothermic and requires careful temperature control to prevent decomposition. The yield can be up to 85%, depending on the purity of starting materials and reaction conditions.

About

CAS No 1067-74-9
English Name Methyl (diethoxyphosphoryl)acetate
Molecular Formula C7H15O5P
Molecular Weight 210.17 g/mol
SMILES CCOP(=O)(CC(=O)OC)OCC
InChIKey CTSAXXHOGZNKJR-UHFFFAOYSA-N
Last Updated: 2025-09-13 09:53

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