4-Iodo-1H-pyrrolo[2,3-b]pyridine(CAS: 319474-34-5)

4-Iodo-1H-pyrrolo[2,3-b]pyridine is a crystalline solid with a molecular weight of approximately 239.03 g/mol. Its solubility in water is low, making it poorly soluble. The compound is moderately reactive towards nucleophiles. It exhibits a melting point of around 180°C and is stable under normal laboratory conditions.

4-Iodo-1H-pyrrolo[2,3-b]pyridine is typically synthesized through an iodination reaction, where pyrrolo[2,3-b]pyridine is treated with iodine in the presence of a Lewis acid catalyst such as aluminum trichloride. The reaction yields the iodinated compound with high selectivity and good to excellent yield.

4-Iodo-1H-pyrrolo[2,3-b]pyridine is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also finds applications in the field of organic chemistry, particularly in the development of novel materials such as polymers and sensors.

When handling 4-Iodo-1H-pyrrolo[2,3-b]pyridine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be handled by professional clean-up services, and the Safety Data Sheet (SDS) should be consulted for detailed instructions.