2-Methylalanyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenylalanyl-L-lysinamide(CAS: 170851-70-4)

The compound 2-Methylalanyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenylalanyl-L-lysinamide is a crystalline solid with a molecular weight of approximately 901.34 g/mol. It has a high solubility in organic solvents such as dimethyl sulfoxide (DMSO) and poor solubility in water. The compound exhibits moderate reactivity towards nucleophiles and can be used in various chemical reactions. It is stable under normal storage conditions but should be protected from moisture and strong acids or bases.

2-Methylalanyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenylalanyl-L-lysinamide is typically synthesized through solid-phase peptide synthesis (SPPS) or solution-phase peptide synthesis. The synthesis involves coupling of amino acids using Fmoc (9-fluorenylmethyloxycarbonyl) chemistry, which provides excellent control over sequence ordering and selectivity. The overall yield is generally moderate to high, depending on the specific reaction conditions and purity of reagents used.

2-Methylalanyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenylalanyl-L-lysinamide is primarily used in the pharmaceutical industry due to its potential as a drug candidate for various diseases. It may also be utilized in polymer chemistry for developing novel materials with specific properties. Additionally, this compound can be employed in the development of sensors and semiconductors, although its specific applications in these areas are limited compared to the pharmaceutical sector.

When handling 2-Methylalanyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenylalanyl-L-lysinamide, it is essential to follow standard laboratory safety practices. Wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work in a well-ventilated area, preferably in a fume hood, to minimize exposure to the compound. If a spill occurs, immediately clean it up using appropriate absorbent materials and dispose of the waste according to local regulations. Refer to the Safety Data Sheet (SDS) for specific handling and storage instructions.