3-Bromo-2-chloro-5-(trifluoromethyl)pyridine(CAS: 71701-92-3)

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 316.03 g/mol. It has a low water solubility and is moderately soluble in common organic solvents like dichloromethane and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is not flammable but requires appropriate handling in a fume hood to avoid inhalation and skin contact.

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine is typically synthesized by bromination of 2-chloro-5-(trifluoromethyl)pyridine using N-bromosuccinimide (NBS) as the brominating agent. The reaction is carried out in an inert solvent like dichloromethane. The yield can be enhanced by using a radical initiator and controlling the reaction temperature and time to achieve high selectivity.

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine is used in various industries, particularly in the pharmaceutical sector for the synthesis of complex organic molecules. It also finds applications in the development of sensors and as a precursor in the semiconductor industry for the production of electronic materials.

When handling 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to prevent inhalation. In case of spills, immediately clean up with appropriate absorbents and follow the guidelines in the Safety Data Sheet (SDS) for disposal.