3-{[(3-Chlorophenyl)sulfonyl]amino}benzoic acid(CAS: 78922-04-0)

3-{[(3-Chlorophenyl)sulfonyl]amino}benzoic acid is a crystalline solid with a molecular weight of approximately 348.04 g/mol. It has a pKa of about 3.7 and is soluble in water and organic solvents. This compound is moderately reactive, especially in basic conditions, and can undergo hydrolysis and sulfoxide reduction.

3-{[(3-Chlorophenyl)sulfonyl]amino}benzoic acid is typically synthesized via a multi-step reaction involving the coupling of 3-chlorobenzenesulfonyl chloride with an amino derivative of benzoic acid. Common synthetic methods include the use of coupling agents and bases, with yields generally ranging from 60% to 80%.

3-{[(3-Chlorophenyl)sulfonyl]amino}benzoic acid is often used in the pharmaceutical industry for the synthesis of various drugs. It also has applications in the polymer industry for modifying properties of polymers, in sensor technology for detecting specific compounds, and in semiconductor manufacturing for etching and cleaning processes.

When handling 3-{[(3-Chlorophenyl)sulfonyl]amino}benzoic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a fume hood to minimize exposure to vapors. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.