1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride (1:1)(CAS: 52605-52-4)

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride (CAS: 52605-52-4) is a crystalline solid with a molecular weight of approximately 431.69 g/mol. It has a pKa of about 1.5 and is moderately soluble in water. The compound exhibits good solubility in organic solvents such as ethanol and acetonitrile. It is relatively stable under normal conditions but should be handled in a fume hood to avoid inhalation. Reactivity is minimal under typical laboratory conditions, but care should be taken during synthesis and handling to avoid direct contact and inhalation. This compound is often used in pharmaceutical and chemical research applications.

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride is typically synthesized by the reaction of 4-(3-chloropropyl)piperazine with 3-chlorophenol in the presence of an acid catalyst such as sulfuric acid. The reaction is usually carried out under reflux, and the product is then hydrochlorinated to form the hydrochloride salt. The yield is typically around 85-90%, and the product is purified by recrystallization from a suitable solvent. This method ensures the formation of the desired product with good selectivity and yield.

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride (CAS: 52605-52-4) is primarily used in the pharmaceutical industry for its potential therapeutic applications, particularly in central nervous system research. It has also found applications in the polymer industry, where it serves as a stabilizer or additive. Additionally, this compound is used in the development of sensors and as a precursor in semiconductor manufacturing due to its unique physicochemical properties.

When handling 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride (CAS: 52605-52-4), it is essential to take appropriate precautions to ensure safety. Wear proper personal protective equipment (PPE), including gloves and safety goggles, and work in a well-ventilated area or fume hood. Avoid inhalation and direct contact with the skin and eyes. In case of a spill, immediately clean up using the appropriate absorbent material and dispose of it according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and disposal information.