3-Hydroxy-4-nitrobenzoic acid(CAS: 619-14-7)

3-Hydroxy-4-nitrobenzoic acid is a crystalline solid with a molecular weight of 214.08 g/mol. It has a solubility of approximately 1.4 g/100 mL in water. This compound is moderately acidic and exhibits good solubility in common organic solvents like ethanol and acetone. It is relatively stable under normal conditions but can be sensitive to strong reducing agents and bases.

3-Hydroxy-4-nitrobenzoic acid can be synthesized via nitration of 3-hydroxybenzoic acid using concentrated nitric acid and sulfuric acid as the nitrating mixture. Alternatively, it can be produced by nitration of 3-hydroxybenzaldehyde followed by oxidation. The yield is around 70-80%, and the reaction is typically conducted under controlled conditions to ensure selectivity.

3-Hydroxy-4-nitrobenzoic acid is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the production of drugs that require specific functional groups. It also finds applications in the production of dyes, pigments, and other organic materials. Additionally, it is used in the manufacturing of sensors and as a component in some polymer formulations.

When handling 3-Hydroxy-4-nitrobenzoic acid, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Handle the compound in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up carefully using appropriate absorbent materials, and the area should be decontaminated. Always refer to the safety data sheet (SDS) for detailed handling procedures and emergency response instructions.