1-bromo-2-methyl-4-nitro-benzene(CAS: 7149-70-4)

1-Bromo-2-methyl-4-nitro-benzene is a crystalline solid with a molecular weight of approximately 228.04 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol, acetone, and dichloromethane. This compound is known for its reactivity towards nucleophiles, particularly in substitution reactions, and its stability under acidic and basic conditions varies depending on the specific reaction conditions.

1-Bromo-2-methyl-4-nitro-benzene is commonly synthesized through the reaction of 4-nitrobenzyl bromide with 2-methylphenol in the presence of a base such as sodium hydroxide. The reaction proceeds via a nucleophilic substitution mechanism, yielding the desired product with good selectivity and yield.

1-Bromo-2-methyl-4-nitro-benzene is used in various industries, particularly in the pharmaceutical sector for the synthesis of certain drug intermediates. It also finds applications in the production of dyes, pigments, and as an intermediate in the development of new materials such as polymers and sensors. Its use in semiconductor industry is less common but can be relevant for specific applications requiring specific chemical functionalities.

When handling 1-bromo-2-methyl-4-nitro-benzene, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a laboratory coat. Work should be conducted in a fume hood to minimize exposure to fumes. Spills should be handled carefully using appropriate absorbent materials, and the area should be cleaned thoroughly. Always refer to the Safety Data Sheet (SDS) for detailed information on handling, storage, and disposal.