3,5-Dibromo-1H-indole(CAS: 81387-89-5)

3,5-Dibromo-1H-indole (CAS: 81387-89-5) is a solid, crystalline compound with a molecular weight of approximately 263.04 g/mol. It has a melting point of about 230-232°C and limited water solubility. This compound is less reactive compared to its parent compound, indole, but shows notable reactivity in aromatic substitution reactions.

3,5-Dibromo-1H-indole is typically synthesized through the bromination of indole using bromine and a Lewis acid catalyst, such as aluminum trichloride. The reaction involves the electrophilic aromatic substitution of indole with bromine, leading to the formation of the dibromo derivative with good yield and selectivity.

3,5-Dibromo-1H-indole (CAS: 81387-89-5) is used in the pharmaceutical industry for the synthesis of intermediates and drugs, as well as in the chemical industry for the development of sensors and semiconductors. It is also explored in the field of polymer chemistry for the modification of polymer properties.

When handling 3,5-Dibromo-1H-indole (CAS: 81387-89-5), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be stored in a fume hood to minimize inhalation risks. In case of a spill, immediate cleanup should be performed using appropriate absorbent materials, and the area should be properly ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.