5-(Benzyloxy)-2-bromopyridine(CAS: 630120-99-9)

5-(Benzyloxy)-2-bromopyridine is a crystalline solid with a molecular weight of approximately 286.03 g/mol. It has a solubility of about 0.1 g/L in water and is slightly soluble in common organic solvents like ethanol and acetone. This compound is reactive towards nucleophiles and is prone to substitution reactions. It is used in synthetic organic chemistry as a starting material and intermediate.

5-(Benzyloxy)-2-bromopyridine is typically synthesized through a multi-step process involving the protection of a pyridine ring with benzyloxy group followed by bromination. Commonly, benzyl bromide reacts with 2-hydroxy-5-pyridinecarboxylic acid to form the benzyloxy derivative. The bromination step is often carried out using N-bromosuccinimide (NBS) or hydrogen bromide in the presence of a catalyst like azobisisobutyronitrile (AIBN).

5-(Benzyloxy)-2-bromopyridine is primarily used in the pharmaceutical and chemical industries as an intermediate for the synthesis of various drugs and materials. It plays a crucial role in the development of new chemical entities and polymers, as well as in the production of sensors and semiconductors.

Proper personal protective equipment (PPE) including gloves, goggles, and a lab coat should be worn when handling 5-(Benzyloxy)-2-bromopyridine. The compound should be handled in a well-ventilated fume hood due to its reactivity. In case of a spill, it should be cleaned up with absorbent material and disposed of according to local regulations. For detailed safety information, a Material Safety Data Sheet (MSDS) should be consulted.