Compound Q&A

How is 5-(Benzyloxy)-2-bromopyridine (CAS: 630120-99-9) typically synthesized?

Answer

5-(Benzyloxy)-2-bromopyridine
5-(Benzyloxy)-2-bromopyridine is typically synthesized through a multi-step process involving the protection of a pyridine ring with benzyloxy group followed by bromination. Commonly, benzyl bromide reacts with 2-hydroxy-5-pyridinecarboxylic acid to form the benzyloxy derivative. The bromination step is often carried out using N-bromosuccinimide (NBS) or hydrogen bromide in the presence of a catalyst like azobisisobutyronitrile (AIBN).

About

English Name 5-(Benzyloxy)-2-bromopyridine
Molecular Formula C12H10BrNO
Molecular Weight 264.12 g/mol
SMILES C1=CC=C(C=C1)COC2=CN=C(C=C2)Br
InChIKey KKCMCYRLJVVNTQ-UHFFFAOYSA-N
Last Updated: 2025-10-23 07:31

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