Methyl 6-bromo-1-isopropyl-1H-indazole-4-carboxylate(CAS: 1346702-52-0)

Methyl 6-bromo-1-isopropyl-1H-indazole-4-carboxylate is a solid with a crystalline form. Its molecular weight is approximately 347.03 g/mol. The compound has limited water solubility but excellent solubility in organic solvents like DMSO and acetonitrile. It exhibits moderate reactivity in nucleophilic substitution reactions and is stable under normal conditions but requires handling in a fume hood to avoid inhalation exposure.

Methyl 6-bromo-1-isopropyl-1H-indazole-4-carboxylate can be synthesized through the reaction of 1-isopropyl-1H-indazole-4-carboxylic acid with bromine in the presence of a base such as sodium hydride. The key steps involve the bromination of the free carboxylic acid group to form the corresponding bromide, followed by its esterification with methyl alcohol. The reaction yields a high purity product with good selectivity and excellent yield.

Methyl 6-bromo-1-isopropyl-1H-indazole-4-carboxylate is primarily used in the pharmaceutical industry for the synthesis of various indazole derivatives with potential medicinal applications. It is also explored in the chemical sensor industry for its reactivity and stability. Additionally, it may have applications in the development of organic semiconductors and as a precursor in polymer chemistry.

When handling Methyl 6-bromo-1-isopropyl-1H-indazole-4-carboxylate, it is essential to use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation exposure. Spills should be handled using appropriate absorbents and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency response procedures.