4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride(CAS: 184475-70-5)

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride is a crystalline solid with a molecular weight of approximately 433.68 g/mol. It has a solubility of about 100 mg/mL in water and moderate solubility in organic solvents. It is highly reactive towards nucleophiles and can undergo substitution reactions. The compound is stable under normal conditions but should be stored at room temperature away from direct sunlight.

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride is typically synthesized via a multi-step process involving the condensation of 7-methoxyquinazoline-6-carbaldehyde with 3-chloro-4-fluoroaniline, followed by acetylation and hydrochloride formation. The synthesis involves the use of catalysts such as piperidine and requires careful control of reaction conditions to achieve high yield and selectivity.

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride is primarily used in the pharmaceutical industry for its potential in developing new therapeutic agents. It may also find applications in sensor technology, where its chemical reactivity and stability make it suitable for detecting specific analytes. Additionally, it could have potential uses in the semiconductor industry for its electronic properties.

When handling 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride, it is crucial to wear appropriate personal protective equipment (PPE) including gloves and safety goggles. Work should be conducted in a well-ventilated fume hood to minimize inhalation risks. In case of a spill, it should be cleaned up using appropriate spill control measures, and the area should be thoroughly rinsed. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.