Compound Q&A
How is 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride (CAS: 184475-70-5) typically synthesized?
Answer
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride is typically synthesized via a multi-step process involving the condensation of 7-methoxyquinazoline-6-carbaldehyde with 3-chloro-4-fluoroaniline, followed by acetylation and hydrochloride formation. The synthesis involves the use of catalysts such as piperidine and requires careful control of reaction conditions to achieve high yield and selectivity.
About
CAS No
184475-70-5
English Name
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride
Molecular Formula
C17H14Cl2FN3O3
Molecular Weight
398.2 g/mol
SMILES
CC(=O)OC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC.Cl
InChIKey
RBFWFFFXYPQXHG-UHFFFAOYSA-N
Last Updated: 2025-10-28 15:15
