Ethyl 6-chloro-3-methyl-2-pyridinecarboxylate(CAS: 850864-54-9)

Ethyl 6-chloro-3-methyl-2-pyridinecarboxylate (CAS: 850864-54-9) is a crystalline compound with a molecular weight of approximately 242.68 g/mol. It has low water solubility and is soluble in organic solvents. This compound exhibits moderate reactivity, particularly with nucleophiles. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

Ethyl 6-chloro-3-methyl-2-pyridinecarboxylate (CAS: 850864-54-9) can be synthesized via a Friedel-Crafts acylation reaction, where ethyl acetoacetate is acylated with 3-chloro-6-methylpyridine in the presence of aluminum chloride as a catalyst. This method provides high selectivity and yield, making it a common route for preparation.

Ethyl 6-chloro-3-methyl-2-pyridinecarboxylate (CAS: 850864-54-9) is utilized in the pharmaceutical industry for the synthesis of certain active pharmaceutical ingredients (APIs). It also has applications in the polymer industry as a monomer for specific polymer synthesis. Additionally, it can be used in the production of sensors and semiconductors.

When handling Ethyl 6-chloro-3-methyl-2-pyridinecarboxylate (CAS: 850864-54-9), laboratory personnel should wear appropriate personal protective equipment (PPE), including gloves and safety goggles. It should be stored in a well-ventilated area and handled with care to avoid inhalation or skin contact. In the event of a spill, it is essential to follow proper safety protocols and refer to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) for detailed instructions.