trans-1,4-Cyclohexanedicarboxylic acid(CAS: 619-82-9)

Trans-1,4-Cyclohexanedicarboxylic acid is a colorless crystalline solid with a molecular weight of 216.23 g/mol. It has a pKa of 4.5 and is slightly soluble in water. This compound exhibits relatively low reactivity compared to other carboxylic acids, making it suitable for various chemical transformations. It has a melting point of 161-162°C and a boiling point of 234-235°C. It is sparingly soluble in water but soluble in organic solvents like ethanol and acetone.

Trans-1,4-Cyclohexanedicarboxylic acid is typically synthesized via the oxidation of 1,4-cyclohexanedimethanol. This process involves treating the alcohol with a strong oxidizing agent such as potassium permanganate in the presence of sulfuric acid. The reaction yields a high yield of the desired diacid. Another method involves the dehydration of maleic acid to form the cis-1,4-cyclohexanedicarboxylic acid, which is then isomerized to the trans isomer under elevated temperature and pressure conditions.

Trans-1,4-Cyclohexanedicarboxylic acid is widely used in the polymer industry, particularly in the production of polyesters and polyamides. It is also utilized in the pharmaceutical sector for the synthesis of certain drugs, as well as in the production of sensors and semiconductors. Its excellent thermal stability and chemical resistance make it a valuable component in various industrial applications.

When handling trans-1,4-Cyclohexanedicarboxylic acid, it is essential to wear appropriate personal protective equipment (PPE) including safety goggles, gloves, and a lab coat. Ensure the use of a fume hood to minimize exposure to vapor. Spills should be handled by cleaning up with appropriate neutralizing agents, followed by thorough rinsing. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions. Due to its low reactivity, it is generally safe, but proper precautions should always be taken when working with any chemical.