Methyl 2,6-difluoro-3-nitrobenzoate(CAS: 84832-01-9)

Methyl 2,6-difluoro-3-nitrobenzoate (CAS: 84832-01-9) is a crystalline solid with a molecular weight of approximately 237.07 g/mol. It has a low solubility in water but is more soluble in common organic solvents such as ethanol and acetone. The compound is moderately reactive, particularly with reducing agents and bases. It has a pKa of around 2.5, indicating its acidic nature.

Methyl 2,6-difluoro-3-nitrobenzoate can be synthesized through the nitration of 2,6-difluorobenzoic acid followed by esterification with methanol. Commonly, this process involves the use of nitric acid and sulfuric acid as the nitrating mixture, with precise temperature control to ensure the desired product is formed with high selectivity and yield. Post-synthesis, the product is typically purified by recrystallization.

Methyl 2,6-difluoro-3-nitrobenzoate (CAS: 84832-01-9) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It also finds applications in the production of certain polymers and in the development of sensors and semiconductors due to its unique chemical properties.

Proper personal protective equipment (PPE) should always be worn when handling Methyl 2,6-difluoro-3-nitrobenzoate (CAS: 84832-01-9), including gloves, safety goggles, and a lab coat. This compound should be used in a well-ventilated area or a fume hood. Spills should be handled with great care, and the Material Safety Data Sheet (MSDS) should be consulted for specific spill procedures. Storage should be in a cool, dry place away from heat sources and incompatible materials.