(5-Bromo-2-thienyl)acetonitrile(CAS: 71637-37-1)

(5-Bromo-2-thienyl)acetonitrile is a crystalline solid with a molecular weight of approximately 229.04 g/mol. It is slightly soluble in water but more soluble in organic solvents like dichloromethane. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. Its physical properties include a melting point of around 60-62°C.

(5-Bromo-2-thienyl)acetonitrile can be synthesized via the bromination of 2-thienylacetonitrile followed by purification. Common methods include the use of N-bromosuccinimide (NBS) as a brominating agent in an organic solvent. The reaction is typically carried out at room temperature, with a yield of about 75-85%.

(5-Bromo-2-thienyl)acetonitrile is used in various industries, particularly in the pharmaceutical sector for the synthesis of intermediates in drug development. It is also used in the polymer industry for the production of certain plastics and resins, and in semiconductor manufacturing for photolithography processes.

When handling (5-Bromo-2-thienyl)acetonitrile, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. The compound should be handled in a fume hood due to its potential for inhalation hazards. Spills should be handled carefully, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed safety information.