2-Fluoro-5-iodopyrimidine(CAS: 697300-79-1)

2-Fluoro-5-iodopyrimidine (CAS: 697300-79-1) is a white or off-white crystalline solid with a molecular weight of approximately 287.03 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetonitrile. The compound is known for its reactive nature, particularly with nucleophiles, and it shows good stability under normal conditions but requires careful handling to prevent hydrolysis.

2-Fluoro-5-iodopyrimidine (CAS: 697300-79-1) is typically synthesized through a multi-step process involving the iodination of a 2-fluoropyrimidine derivative. Commonly, the reaction uses iodine and a Lewis acid such as aluminum chloride as a catalyst. The yield is around 60-70%, and the reaction is carried out in an aprotic solvent like dichloromethane. The product is purified through recrystallization and characterized by NMR and mass spectrometry.

2-Fluoro-5-iodopyrimidine (CAS: 697300-79-1) is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds applications in the semiconductor industry for producing photolithography resists and in the polymer industry for developing novel materials with specific thermal and mechanical properties. Additionally, it is used in the development of sensors for detecting specific chemical and biological entities.

When handling 2-Fluoro-5-iodopyrimidine (CAS: 697300-79-1), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight and heat sources. Operations should be carried out in a well-ventilated fume hood to minimize exposure to air. In case of spillage, immediately clean up the area using appropriate absorbent materials and follow the safety data sheet (SDS) guidelines for disposal. Always refer to the latest SDS for detailed safety information.