Temsirolimus(CAS: 162635-04-3)

Temsirolimus (CAS: 162635-04-3) is a macrocyclic lactam, characterized by a molecular weight of approximately 737.85 g/mol. It is sparingly soluble in water and ethanol. Chemically, it is relatively stable but can be hydrolyzed under basic conditions. It crystallizes in the form of a white to off-white powder and is typically stored at room temperature and protected from light.

Temsirolimus (CAS: 162635-04-3) is synthesized through a complex multi-step process that includes acylation, cyclization, and amidation reactions. A key step involves the use of a chiral catalyst for enantioselective synthesis. The overall process yields up to 85% of the desired product, with the final product purified by chromatography and crystallization.

Temsirolimus (CAS: 162635-04-3) is primarily used in the pharmaceutical industry for the treatment of renal cell carcinoma and lymphangioleiomyomatosis. It is also of interest in the research and development of new therapies for various cancers and autoimmune diseases. Its applications extend to academic and industrial research in the field of biotechnology.

When handling Temsirolimus (CAS: 162635-04-3), appropriate personal protective equipment (PPE) such as gloves and safety glasses should be worn. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, it should be immediately cleaned up using appropriate materials. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.