7-Bromo-1H-indazole-3-carboxylic acid(CAS: 885278-71-7)

7-Bromo-1H-indazole-3-carboxylic acid is a crystalline solid with a molecular weight of 267.04 g/mol. It has a low solubility in water (0.01 g/100 mL at 20°C) and is more soluble in organic solvents like methanol and acetonitrile. The compound shows moderate reactivity under basic conditions and is relatively stable under acidic conditions. It is known for its poor solubility and weak basicity.

7-Bromo-1H-indazole-3-carboxylic acid is typically synthesized through a bromination reaction of 1H-indazole-3-carboxylic acid or its derivates. This process involves the use of a brominating agent like N-bromosuccinimide (NBS) in the presence of a suitable catalyst such as azobisisobutyronitrile (AIBN) under UV light. The yield is moderate, and the method is selective for the bromination at the indazole ring.

7-Bromo-1H-indazole-3-carboxylic acid is used in various industries, including pharmaceuticals, where it serves as an intermediate for the synthesis of drugs with potential therapeutic applications. It also finds use in the polymer industry for the development of new materials and in the sensor industry for the fabrication of chemical sensors. Additionally, it is explored in the semiconductor industry for specific applications.

When handling 7-Bromo-1H-indazole-3-carboxylic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up carefully, and the area should be properly decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed guidelines and emergency procedures.