Rupatadine(CAS: 158876-82-5)

Rupatadine is a white to off-white crystalline compound. Its molecular weight is approximately 325.31 g/mol. It is slightly soluble in water and has a pKa around 10.5. Chemically, it is a histamine H1 receptor antagonist with good stability under standard storage conditions.

Rupatadine is synthesized via a multi-step process, starting with the synthesis of the key intermediate, 3-(4-chlorophenyl)-N-(2,6-dichlorophenyl)propan-1-amine, followed by coupling with a suitable alcohol under catalysis by a palladium-based catalyst, achieving a yield of about 75%.

Rupatadine is primarily used in the pharmaceutical industry for the treatment of allergic rhinitis and pruritus. It is also explored in the cosmetics industry for its anti-itching properties. Additionally, due to its chemical structure, it may have potential applications in other sectors such as drug delivery systems and topical treatments.

When handling Rupatadine, it is essential to use personal protective equipment (PPE) such as gloves and goggles. It should be stored in a cool, dry place away from direct sunlight. Spills should be cleaned up with caution, and the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) should be consulted for specific procedures. Fume hoods should be used during its handling to minimize inhalation risks.