3-Chloro-2-fluorobenzoic acid(CAS: 161957-55-7)

3-Chloro-2-fluorobenzoic acid is a crystalline solid with a molecular weight of approximately 191.58 g/mol. It has a pKa of about 3.1 and is sparingly soluble in water. This compound is reactive, particularly in its carboxylic acid functionality, and it can undergo esterification and acid-base reactions.

3-Chloro-2-fluorobenzoic acid can be synthesized via the reaction of 2-fluorobenzoic acid with thionyl chloride. The reaction is carried out under mild conditions, with a yield of approximately 90%. This method involves the substitution of a hydrogen atom on the carboxylic acid group with a chlorine atom.

3-Chloro-2-fluorobenzoic acid is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the production of dyes, sensors, and in materials science for the development of polymers and semiconductors.

When handling 3-Chloro-2-fluorobenzoic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from heat sources. Spills should be handled with care, and it is recommended to use a fume hood to minimize exposure. Always refer to the Safety Data Sheet (SDS) for detailed safety information.