5-Bromo-2-fluorocinnamic acid(CAS: 202865-71-2)

5-Bromo-2-fluorocinnamic acid is a crystalline solid with a molecular weight of approximately 241.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and acetone. Chemically, it is moderately reactive, especially towards nucleophiles. It is commonly used in organic synthesis and medicinal chemistry.

5-Bromo-2-fluorocinnamic acid is synthesized through a series of steps, starting with 2-fluorocinnamic acid. Bromination is achieved using bromine in the presence of a Lewis acid like aluminum bromide. The reaction is typically carried out in an inert solvent like dichloromethane, with a yield of around 70-80% and good selectivity.

5-Bromo-2-fluorocinnamic acid is primarily used in the pharmaceutical industry for the synthesis of drug candidates. It also finds applications in the polymer industry for the development of functional materials, and in the semiconductor industry for the production of materials used in sensor technologies.

When handling 5-Bromo-2-fluorocinnamic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure to bromine and other fumes. Spills should be cleaned up using appropriate absorbent materials, and the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) should be consulted for detailed spill procedures.