Tert-butyl chlorosulfonylcarbamate(CAS: 147000-89-3)

Tert-Butyl chlorosulfonylcarbamate (CAS: 147000-89-3) is a white crystalline solid with a molecular weight of approximately 199.6 g/mol. It is slightly soluble in water and highly soluble in organic solvents like ethanol and acetonitrile. The compound is known for its reactivity, particularly in nucleophilic substitution reactions. It has a melting point of 118-120°C and is stable under normal storage conditions but requires careful handling due to its reactivity.

Tert-Butyl chlorosulfonylcarbamate (CAS: 147000-89-3) is typically synthesized by the reaction of tert-butyl carbamate with chlorosulfonyl isocyanate. The process involves stirring these reagents together under anhydrous conditions to achieve high yield and selectivity. The reaction is carried out in a suitable solvent such as dichloromethane, and the product is isolated by conventional methods like filtration and recrystallization.

Tert-Butyl chlorosulfonylcarbamate (CAS: 147000-89-3) is primarily used in the pharmaceutical and chemical industries for its reactivity and usefulness in organic synthesis. It serves as an important intermediate in the synthesis of various drugs and other functional materials. Its role in the polymer industry is also significant, where it is used as a cross-linking agent and in the development of new materials with enhanced properties.

When handling Tert-Butyl chlorosulfonylcarbamate (CAS: 147000-89-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. It should be used in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials. Storage should be in a cool, dry place away from direct sunlight. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.