5-Indolinecarboxylic acid(CAS: 15861-30-0)

5-Indolinecarboxylic acid is a crystalline solid with a molecular weight of approximately 147.17 g/mol. Its solubility in water is low, around 0.05 g/L at 20°C. Chemically, it is moderately reactive, showing some acidity and reactivity towards nucleophiles. It is often used in organic synthesis due to its carboxylic acid functionality.

5-Indolinecarboxylic acid is commonly synthesized via the condensation of indoline with carbon dioxide. The reaction typically requires a suitable catalyst such as a metal oxide or an acid. High selectivity and good yield can be achieved under optimized conditions, usually involving reflux or heating under pressure. Detailed procedures are described in various organic synthesis literature.

5-Indolinecarboxylic acid finds applications in multiple industries. It is used in pharmaceuticals for the synthesis of certain drugs, in polymers for the modification of polymer properties, in sensors for detecting specific chemical species, and in semiconductors for the production of organic electronic materials. Its reactivity and functional groups make it versatile for various applications.

When handling 5-Indolinecarboxylic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation of dust. Spills should be cleaned up promptly using appropriate absorbents. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.