Recent advances in radical thiocyanation cyclization or spirocyclization reactions

Literature Information

Publication Date 2023-11-09
DOI 10.1039/D3OB01659E
Impact Factor 3.876
Authors

Qinqin Yan, Shiliu Chen, Jie Fan, Zejiang Li


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Abstract

Organic thiocyanates are valuable biological moities and drug-building blocks. They can also transform effectively into thioethers, thiols, alkynyl thioethers, and thiocarbamates in synthetic chemistry. With respect to the merits of thiocyanates, many chemists and our research team have developed diverse strategies to access SCN-revised heterocycles/spirocycles via an effective radical cyclization process. Hence, this review article first describes the importance/application of thiocyanates. Subsequently, it summarizes the reaction conditions, substrate scopes, and plausible mechanism, respectively, of the excellent work stated above.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
CiteScore: 3.4
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Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

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