Chitosan: an efficient recyclable catalyst for transamidation of carboxamides with amines under neat conditions

Literature Information

Publication Date 2014-07-28
DOI 10.1039/C4GC01402B
Impact Factor 10.182
Authors

Sadu Nageswara Rao, Darapaneni Chandra Mohan, Subbarayappa Adimurthy


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Abstract

A novel chitosan-catalyzed transamidation of carboxamides with amines under solvent-free conditions is described. A series of amide derivatives as well as more challenging aryl and alkyl amines with long-chain alkyl substituents could be selectively converted into the corresponding transamidation products, which are frequently found in biologically active compounds and pharmaceuticals. Under similar reaction conditions benzo[d]heterocycles were also obtained via a one-pot synthesis through transamidation and subsequent dehydration. Recyclability of chitosan was demonstrated, with quantitative yields of products obtained without any loss of catalytic activity.

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