![6-[2-(Trifluoromethoxy)phenyl]-2-pyridinecarboxylic acid structure](https://static.chemtradehub.com/structs/887/887983-48-4-f6ac.webp "6-[2-(Trifluoromethoxy)phenyl]-2-pyridinecarboxylic acid structure")
6-[2-(Trifluoromethoxy)phenyl]-2-pyridinecarboxylic acid
CAS Number:
887983-48-4
Molecular Formula:
C13H8F3NO3
Synthesis, conformational analysis and GalNAc–lectin interactions of a constrained C-glycoside analogue of the TN antigen
Literature Information
Publication Date
2023-12-28
DOI
10.1039/D3NJ05184F
Impact Factor
3.591
Authors
Juliette Dourdan, Florian Rouzier, Thanh Thao Huynh, Sullivan Bricaud, Arnaud Nourry, Stéphane Guillarme
View Original
Abstract
Highly stereoselective 1,3-dipolar cycloaddition allowed the synthesis of the original stable TN antigen mimic presenting a constraint on the amino acid part. Two main conformations of the GalNAc moiety were detected by molecular modelling and NMR. A ligand/protein interaction study was performed by saturation transfer difference NMR analyses using two GalNAc-specific model lectins highlighting that the constrained C-glycoside analog was recognized by these proteins as well as the TN antigen derivative.
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Source Journal
New Journal of Chemistry
CiteScore:
5.3
Self-citation Rate:
3.7%
Articles per Year:
2153
NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.
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