PhNCO-enabled synthesis of secondary amides from N-(2-aminophenyl)benzamides
Literature Information
Publication Date
2023-12-06
DOI
10.1039/D3NJ04995G
Impact Factor
3.591
Authors
Karthick Govindan, Nian-Qi Chen, Alageswaran Jayaram
View Original
Abstract
We have successfully developed an efficient method for synthesizing secondary amides utilizing easily accessible N-(2-aminophenyl)benzamide and phenyl isocyanate. Notably, the leaving group can be easily recuperated as a carbonylated N-heterocycle, which holds notable relevance in pharmaceutical applications. The crux of this strategy involves a sequential nucleophilic/intramolecular addition process of phenyl isocyanate, followed by transamidation. Moreover, the protocol features atom-economy, practicality, a one-pot two-step reaction, and facile preparation of substrates.
Related Literature
Constructing star polymersvia modular ligation strategies
Ozcan Altintas, Andrew P. Vogt, Christopher Barner-Kowollik, Umit Tunca
2011-08-10
Review Article
DOI: 10.1039/C1PY00249J
Recognition of polymer side chains by cyclodextrins
Akihito Hashidzume
2011-06-07
Review Article
DOI: 10.1039/C1PY00162K
Efficient synthesis of poly(2-hydroxypropyl methacrylate)-silica colloidal nanocomposite particles via aqueous dispersion polymerization
Hua Zou, Steven P. Armes
2011-11-17
Paper
DOI: 10.1039/C1PY00406A
Synthesis and characterization of a biodegradable polymer prepared viaradical copolymerization of 2-(acetoacetoxy)ethyl methacrylate and molecular oxygen
Sunirmal Pal, Amit Das, Sankar Maiti, Priyadarsi De
2011-10-26
Paper
DOI: 10.1039/C1PY00419K
Controlled biomimetic silica formation using star-shaped poly(l-lysine)
Qinrong Wang, Jun Yu, Yunsong Yan, Shaoqiang Xu, Fangfang Wang, Qingnan Li, Jinzhi Wang, Xin Zhang, Daojun Liu
2012-03-21
Paper
DOI: 10.1039/C2PY20070H
Enzymatically degradable nanogels by inverse miniemulsion copolymerization of acrylamide with dextran methacrylates as crosslinkers
Daniel Klinger, Eugen M. Aschenbrenner, Clemens K. Weiss, Katharina Landfester
2011-11-18
Paper
DOI: 10.1039/C1PY00415H
Self-assembled poly(2-ethyl-2-oxazoline) fibers in aqueous solutions
Pınar Tatar Güner, Annamária Mikó, Florian F. Schweinberger
2011-12-01
Communication
DOI: 10.1039/C1PY00463H
Facile glycosylation of dendrimers for eliciting specific cell–material interactions
Xiaopeng Liu, Jie Liu, Ying Luo
2011-11-29
Communication
DOI: 10.1039/C1PY00404B
Light-emitting poly(N-naphthyl-2,7-carbazole)
Takeshi Mori, Toshinobu Shinnai
2011-10-10
Paper
DOI: 10.1039/C1PY00286D
You might also like
Compound Q&A
What industries use 4-(4-tert-Butylphenyl)-1H-pyrazol-3-amine (CAS: 1015845-73-4)?
4-(4-tert-Butylphenyl)-1H-pyrazol-3-amine finds applications in various industri...
1015845-73-44-(4-tert-Butylpheny...
Compound Q&A
What industries use H3TATAB (CAS: 63557-10-8)?
H3TATAB is used in the pharmaceutical industry for the synthesis of certain orga...
63557-10-8H3TATAB
Compound Q&A
What are the main uses of 1-Ethyl-3-fluorobenzene (CAS: 696-39-9)?
1-Ethyl-3-fluorobenzene (CAS: 696-39-9) is primarily used as a precursor in the ...
696-39-91-Ethyl-3-fluorobenz...
Compound Q&A
What are the main uses of 1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid (CAS: 851484-94-1)?
1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid is prim...
851484-94-11-(tert-Butoxycarbon...
Compound Q&A
What are the physical and chemical properties of 1-Cyclobutyl-4-piperidinone (CAS: 359880-05-0)?
1-Cyclobutyl-4-piperidinone (CAS: 359880-05-0) is a colorless or white crystalli...
359880-05-01-Cyclobutyl-4-piper...
Compound Q&A
What is Pyridine-2,6-dicarboxylic acid mono-tert-butyl ester (CAS: 575433-76-0)?
Pyridine-2,6-dicarboxylic acid mono-tert-butyl ester (CAS: 575433-76-0) is a che...
575433-76-0Pyridine-2,6-dicarbo...
Compound Q&A
What is the market or research trend for 2,3-Difluorophenylalanine (CAS: 236754-62-4)?
The market for 2,3-Difluorophenylalanine (CAS: 236754-62-4) is growing with incr...
236754-62-42,3-Difluorophenylal...
Compound Q&A
How is (2-Hydroxy-1-naphthyl)boronic acid (CAS: 898257-48-2) typically synthesized?
(2-Hydroxy-1-naphthyl)boronic acid can be synthesized through the reduction of 2...
898257-48-2(2-Hydroxy-1-naphthy...
Compound Q&A
What are the physical and chemical properties of tert-Butyl (5-bromo-6-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate (CAS: 1315351-28-0)?
This compound is a crystalline solid with a molecular weight of approximately 52...
1315351-28-0tert-Butyl (5-bromo-...
Compound Q&A
Are there alternatives to 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl beta-D-glucopyranoside (CAS: 19833-12-6) in synthesis?
While 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl beta-D-gluc...
19833-12-65,7-Dihydroxy-4-oxo-...
Source Journal
New Journal of Chemistry
CiteScore:
5.3
Self-citation Rate:
3.7%
Articles per Year:
2153
NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.
Recommended Compounds
3-(4-(Trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carbohydrazide
CAS Number:
883028-82-8
Molecular Formula:
C10H7F3N4O3
![N-[2-Bromo-4-(trifluoromethoxy)phenyl]formamide structure](https://static.chemtradehub.com/structs/941/941294-53-7-f783.webp "N-[2-Bromo-4-(trifluoromethoxy)phenyl]formamide structure")
N-[2-Bromo-4-(trifluoromethoxy)phenyl]formamide
CAS Number:
941294-53-7
Molecular Formula:
C8H5BrF3NO2
1-(4-Methylphenoxy)-3-(propan-2-ylamino)propan-2-ol
CAS Number:
5790-46-5
Molecular Formula:
C13H21NO2
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.