The design, synthesis, and biological activity assay of malononitrile oxime ether compounds as effective fungicides
Literature Information
Publication Date
2023-11-10
DOI
10.1039/D3NJ03898J
Impact Factor
3.591
Authors
Simin Wang, Zhixiang Zhao, Li Zhang, Jianjun Zhang, Huizhe Lu, Yanhong Dong
View Original
Abstract
Plant pathogenic fungi present a significant risk to crop productivity. The most cost-effective and efficient approach to mitigating plant diseases caused by these pathogenic fungi is using antifungal agrochemicals. In this study, we synthesized two sets of compounds incorporating malononitrile structures. Furthermore, we assessed the fungicidal properties of a subset of crucial intermediates and target compounds against specific agricultural fungi. Additionally, we employed predictive methods to estimate the oral LD50 values of selected target compounds in rats. The results demonstrated that the compounds E, particularly those with malononitrile and 1,2,3-triazole structures, exhibited significant inhibition (over 90%) against Rhizoctonia solani, including compound E11 with an EC50 value of 2.621 mg L−1. The toxicity prediction showed that E11 is a low-toxicity compound. Thus, E11 is a potential candidate for the further development of new R. solani selective inhibitory fungicides.
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Source Journal
New Journal of Chemistry
CiteScore:
5.3
Self-citation Rate:
3.7%
Articles per Year:
2153
NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.
Recommended Compounds
(3beta,7beta,12beta)-3,7,12-Trihydroxy-11,15,23-trioxolanost-8-en-26-oic acid
CAS Number:
98665-22-6
Molecular Formula:
C30H44O8
![[4-(Heptyloxy)phenyl]boronic acid structure](https://static.chemtradehub.com/structs/136/136370-19-9-ad33.webp "[4-(Heptyloxy)phenyl]boronic acid structure")
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