![(3-{[4-(Aminomethyl)-6-(trifluoromethyl)-2-pyridinyl]oxy}phenyl)[(3R,4R)-3-fluoro-4-hydroxy-1-pyrrolidinyl]methanone structure](https://static.chemtradehub.com/structs/200/2007885-39-2-affc.webp "(3-{[4-(Aminomethyl)-6-(trifluoromethyl)-2-pyridinyl]oxy}phenyl)[(3R,4R)-3-fluoro-4-hydroxy-1-pyrrolidinyl]methanone structure")
(3-{[4-(Aminomethyl)-6-(trifluoromethyl)-2-pyridinyl]oxy}phenyl)[(3R,4R)-3-fluoro-4-hydroxy-1-pyrrolidinyl]methanone
CAS Number:
2007885-39-2
Molecular Formula:
C18H17F4N3O3
A fluorescent turn-on probe for visualizing lysosomes in hypoxic tumor cells
Literature Information
Publication Date
2016-04-15
DOI
10.1039/C6AN00369A
Impact Factor
4.616
Authors
Yingchao Liu, Feiyi Wang, Qiang Fei, Ben Shi, Jiancai An, Chunchang Zhao, Chen-Ho Tung
View Original
Abstract
A fluorescent probe for fulfilling a lysosome targeting function in hypoxic tumor cells is reported, wherein azoreductase triggers a dramatic fluorescence enhancement and specific imaging of lysosomes in hypoxic cancer cells.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
5-Bromo-4-chloro-2-(trifluoromethyl)quinazoline
CAS Number:
2089311-03-3
Molecular Formula:
C9H3BrClF3N2
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