Synthesis of novel chromeno[1,6]naphthyridine derivatives in PEG-400 via catalyst-free, one-pot, and multicomponent reactions

Literature Information

Publication Date 2023-11-15
DOI 10.1039/D3NJ03273F
Impact Factor 3.591
Authors

Fatemeh Asilpour, Dariush Saberi, Alireza Hasaninejad


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Abstract

An efficient, one-pot, and catalyst-free pathway was reported for the synthesis of novel chromeno[1,6]naphthyridine derivatives via a multicomponent condensation reaction of salicylaldehyde derivatives, malononitrile dimer, and active methylene compounds. All the reactions were performed in polyethylene glycol-400 as a green solvent at 80 °C. The reactions proceeded with a high-atom economy, and new products were synthesized with good yields and a simple work-up procedure, with water as the only by-product.

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New Journal of Chemistry
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