Ratiometric analysis of reversible thia-Michael reactions using nitrile-tagged molecules by Raman microscopy

Literature Information

Publication Date 2023-11-14
DOI 10.1039/D3CC05015G
Impact Factor 6.222
Authors

Hiroyuki Yamakoshi, Daiki Shibata, Aki Kohyama, Yoshiharu Iwabuchi, Takakazu Nakabayashi


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Abstract

Ratiometric Raman analysis of reversible thia-Michael reactions was achieved using α-cyanoacrylic acid (αCNA) derivatives. Among αCNAs, the smallest derivative, ThioRas (molecular weight: 167 g mol−1), and its glutathione adduct were simultaneously detected in various subcellular locations using Raman microscopy.

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ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

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