Ratiometric analysis of reversible thia-Michael reactions using nitrile-tagged molecules by Raman microscopy
Literature Information
Hiroyuki Yamakoshi, Daiki Shibata, Aki Kohyama, Yoshiharu Iwabuchi, Takakazu Nakabayashi
Ratiometric Raman analysis of reversible thia-Michael reactions was achieved using α-cyanoacrylic acid (αCNA) derivatives. Among αCNAs, the smallest derivative, ThioRas (molecular weight: 167 g mol−1), and its glutathione adduct were simultaneously detected in various subcellular locations using Raman microscopy.
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