Highly photoactive Ir(iii)–Pt(iv) heterometallic conjugates for anticancer therapy

Literature Information

Publication Date 2023-11-28
DOI 10.1039/D3CC04938H
Impact Factor 6.222
Authors

Wangman Hu, Rongzhi Liu, Kai Zheng, Zhigang Wang


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Abstract

For the first time, this study reported the photoactivatable activity of Ir(III)–Pt(IV) heterometallic conjugates, which were stable in the dark and activated to release oxaliplatin and Ir within 3 min of irradiation. The conjugates induced apoptosis and immunologic cell death through Pt–DNA binding and reactive oxygen species generation upon irradiation. This work developed photoactivatable heterometallic agents for anticancer therapy.

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